Front end web development has become quite complex. The exponential growth of tooling options is undeniably a Good Thing but now we as developers need to take a step back. We need to evaluate our needs with a sober un-biased eye. We have proven that we can build highly complex apps and we now must challenge ourselves to build the simplest apps possible.
The Organic Web philosophy proposes that we know the ingredients in our apps. If it does not have a clear and compelling purpose, it's probably not healthy.
Web standards make our lives easier. Apps that follow and embrace web standards are future-proof and lovely to work on. Think very carefully whether the job at hand can be done using a standards-compliant technique, before relying on a third-party library to handle the task.
When writing custom code or employing third-party libraries, strive to code with the utmost clarity. Code should be parseable and understandable at a glance. Not only will this make maintenance easier but it will encourage you to make logical choices during the development process.